The STS-107 launch took place on January 16, 2003 on a perfect cool day. Once Columbia arrived in space the astronauts set up the Spacehab laboratory for their two week science marathon.
Dave had one of the most difficult jobs for a rookie astronaut - going to bed just a couple of hours after launch. He said before the flight, "Well, I think that probably my hardest job on this whole flight is going to be going to sleep the first night. The blue shift, which is three of us [Dave, Mike Brown, and Willie McCool], we will launch actually in the afternoon and evening of our day. So, about four hours after we get to space, it's “nighttime” for us and we need to go to sleep. So, even though I will have had a long day, I think it's probably going to be pretty tough to go climb into bed and go to sleep. That's probably going to be the toughest thing I have to do the whole mission."
Dave was responsible for many of the experiments - both as the operator and guinea pig. He donated blood several times for experiments that studied how the body processes protein and calcium. His body was used to study the heart and lungs, he ignited tiny flames, and he aimed an Israeli camera to search for dust clouds and lightning on Earth.
Early in the mission, Dave performed a blood draw on crewmate, Mike Anderson - or at least he tried to. The first two times that Dave stuck the needle into Mike's arm, he couldn't find the vein. Dave radioed mission control, "We have a good chance on the third try!" and added, "I don't mind at all." – Of course, he was on the correct side of the needle! Mission control said it was okay if Mike agreed. A couple of minutes later, Dave radioed that the third try was successful. The next day mission control emailed the astronauts, "Special thanks to Mike for 'sticking' it out and giving Dave one more chance to get that container filled. After yesterday, the entire payload crew can truly say - 'I gave at the office!'"
A European experiment tested Dave's heart and lungs. Before the mission Dave noted, "One of the ones that I find very interesting, particularly as a physician, is the question of whether lungs work better if you're lying on your stomach or on your back. If you're healthy, this really doesn't matter. But if you're really sick - say, you're in a hospital, you're seriously ill, you've been in a car wreck, or you have a family member who has been - the question is, Would it be better to roll you over onto your stomach if you're on a respirator in an intensive care unit?" Dave had a personal interest in the experiment: he was dating Janneke Gisolf, one of the European team's graduate students and the two were even discussing potential baby names.
Dave was one of the astronauts responsible for creating tiny flame balls in a sealed container. Things were going well when Dave suddenly announced, "I see one flame ball and its name is Howard." The scientists wondered, "Why did he give it a name and who's Howard?". Later Dave declared, "This one's a girl, and its name is Samantha." Nobody knows why Dave decided to start naming the flame balls, but it was enjoyable for everybody involved. The flame balls were a great hit and ended on a high note - nine simultaneous flame balls, including one which lasted for an incredible 81 minutes.
Dave operated an Israeli dust experiment. A special camera took video images of dust clouds below, and could also be used to image lightning shooting upwards from clouds. Scientists on the ground instructed Dave where to point the camera, and the early lightning runs were a pleasant surprise. Dave said, "I [just] ran the video recorders, the cameras in the payload bay. It was the ground that actually discovered this very brief phenomenon. It's not something we've been able to see with our eyes - at least I haven't. So the 'oh wow' time came a couple of days later when we got a message from the ground and a picture showing this thing that we had filmed, and I was fortunate enough to be the camera operator for it. That was one of the real highlights on the flight for me."
After an amazingly productive 16 days in space, Dave and his crewmates prepared space shuttle Columbia for its journey home.
Columbia reentered the Earth's atmosphere on February 1, 2003. A damaged wing resulted in Columbia breaking apart over Texas.
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